Evidence-Guidance Community Window_COVID-NMA_v1.1.docx

Evidence/Guidance Community Window

This page is for organizations focused on synthesizing evidence and producing clinical guidance to document best practices, tools, resources, needs, and other aspects of their work. The purpose of the documentation is to facilitate the uptake of high-quality evidence and guidance into clinical decision support and performance measures, to highlight best practice, and to foster inter-agency cooperation and support within the knowledge ecosystem for COVID-19 and beyond. The first set of tables apply broadly to COVID-19 (and other targets), and the second set of tables refer to evidence and guidance specifically related to the Collaborative’s current focus targets; i.e., COVID-19 testing and triage, and anticoagulant use.

Those providing data for these tables should consider, "What do you want those who seek to implement 'living guidance' to know about evidence synthesis and guidance development strategies and tools to make their efforts more successful? Likewise, "What do you want to know about efforts of others working in the knowledge ecosystem to make your efforts more successful?"

Overarching Description of Evidence Synthesis/Guideline Development Community Best Practices, Tools, Resources

	Identify (Search/Screen) Primary Studies	Synthesize Evidence (including Assessing Quality)
Current Approach [1]	Monitoring new trials and reviews on the L*VE Epistemonikos platform and the Cochrane COVID-19 study register	For each new RCT record and publish key information in a trial network map Undertake risk of bias assessment Extract data relating to pre-determine outcomes, create and publish forest plots of quantitative data as appropriate Undertake GRADE evidence profiles for all comparisons Update and maintain GRADE evidence profiles as more trials are published
Pearls/Tips Learned	We have determined that monitoring and searching the two sources above precludes the need for other individual database searches	We have developed a tool for monitoring the preprint servers to identify changes to the data presented.
Desired Approach	Map of all RCTs for prevention and treatment of COVID-19 including vaccines and rehabilitation	We have initiated communication with all trialists to try to ensure consistent approaches e.g. selection of outcomes, reduction of risk of bias, and to invite them to contribute missing data. We also aim to request individual participant data
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] _x_Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply _x_Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] _x_Consistency of outcomes [Details:] _x_Engagement with primary researchers and upstream stakeholders [Details:] _x_Engagement with decision makers and other downstream stakeholders [Details:] __Other [Details:]
Support You Can Provide Other Participants	Living network mapping of RCTs: Metadata and other details of primary studies included in our evidence syntheses	Living comprehensive assessment of all RCTs that address prevention and treatment of COVID-19 Living evidence syntheses and network meta-analysis as appropriate.

	Produce Guidance	Make Guidance Computable
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]
Support You Can Provide Other Participants

	Implement Guidance (e.g., as CDS, eCQMs)	Analyze Results (e.g., care outcomes)	Apply Results (e.g., Quality Improvement, create evidence)
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]
Support You Can Provide Other Participants

Drill Down into Evidence Synthesis/Guideline Development Community Best Practices, Tools, Resources For ACTS Collaborative Focus Targets

COVID-19 Testing/Triage (ED and ambulatory settings)

	Identify (Search/Screen) Primary Studies	Synthesize Evidence (including Assessing Quality)
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Consistency of outcomes [Details:] __Engagement with primary researchers and upstream stakeholders [Details:] __Engagement with decision makers and other downstream stakeholders [Details:] __Other [Details:]
Support You Can Provide Other Participants

	Produce Guidance	Make Guidance Computable
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]
Support You Can Provide Other Participants

	Implement Guidance (e.g., as CDS, eCQMs)	Analyze Results (e.g., care outcomes)	Apply Results (e.g., Quality Improvement, create evidence)
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]
Support You Can Provide Other Participants

Anticoagulation

	Identify (Search/Screen) Primary Studies	Synthesize Evidence (including Assessing Quality)
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Consistency of outcomes [Details:] __Engagement with primary researchers and upstream stakeholders [Details:] __Engagement with decision makers and other downstream stakeholders [Details:] __Other [Details:]
Support You Can Provide Other Participants

	Produce Guidance	Make Guidance Computable
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]
Support You Can Provide Other Participants

	Implement Guidance (e.g., as CDS, eCQMs)	Analyze Results (e.g., care outcomes)	Apply Results (e.g., Quality Improvement, create evidence)
Current Approach
Pearls/Tips Learned
Desired Approach
Needs to Achieve Desired Approach	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]	Check all that apply __Better source/input materials [Details: ] __Common format/terminologies for managing/sharing data [Details: ] __Other [Details:]
Support You Can Provide Other Participants

[1] For this row and the next, include URLs/pointers to documents outlining steps to accomplish the tasks, tools that support this work and/or other items critical for others working along the evidence/knowledge to know about to make their work optimally efficient, appropriate and effective.