Overview

This page is a resource to help stakeholders working along the COVID-19 evidence-to guidance- to action - to data - to evidence cycle improve their work processes and results. The ultimately goal is to a soon as possible, improve COVID-19 care delivery and outcomes.
The tables below are designed to aggregate Collaborative participant recommendations for addressing steps in this COVID-19 knowledge ecosystem. The recommended tools and approaches are being gathered and will evolve over time as stakeholder input is received and community consensus around best practices - and the pandemic itself - evolve.

Recommendation Tables for Knowledge Ecosystem Steps

Table List

Identify Studies
Synthesize Evidence
Produce Guidance
Make Guidance Computable
Implement Guidance
Analyze Care Results
Leverage Results Analysis (e.g., for Quality Improvement, Reporting, Evidence Generation)

Identify Studies

	General Recommendations	Testing/Triage
Input Sources	L*VE/Epistemonikos Cochrane COVID-19 study register NIPH COVID-19 Living Evidence Map MedRxiv ClinicalTrials.gov/COVID-19 New pubmed interface DoctorEvidence CORD-19 Dataset Search EBSCO COVID-19 Information Portal University of Michigan COVID-19 Best Evidence Front Door	NEWS2 predicts severity/mortality at admission Annals IM, hospitalized patient trajectories Sensitivity, Specificity Predictive Values of Tests for COVID-19 in ED PREDI-CO Risk assessment tool
Search Strategies
Output Repositories
Current Standards
Emerging Standards
Initiatives	Librarian Reserve Corps COVID-Evidence Project - building a database to gather all the evidence around a drug (University of Basil - currently focused on hydroxychloroquine, but model could be adaptable to other targets) Identification of sources to identify primary studies - validation study of specialized COVID-19 databases (systematic reviewers are going to different sources - this effort is to identify best practices) Advocate for librarian representation in searches and reviews - leverage skillsets/best practices in this work [SLMC]: close gaps between needs that clinicians are seeing on the front line and topics covered in reviews guidelines COKA Evidence/ Tools WG [Project Google Drive](work in process)
Tools/ Platforms
Other Best Practices

Synthesize Evidence

	General Recommendations	Anticoagulation	Testing/Triage
Input Sources	See Sources/Repositories from Identify Studies table ClinicalTrials.gov/COVID-19; New pubmed interface; DoctorEvidence CORD-19 Dataset Search	Underlying justification and evidence tables (critically ill and acutely ill) from ASH Anticoagulation Living Guidelines L*VE/Epistemonikos search on antithrombotics; can send email when new study/review/guideline is published. Rapid Cochrane review on anticoagulation in COVID-19 patients	BMJ EBM rapid review on COVID tests
Output Repositories	SRDR+ COVID NMA Project COVID-END Best Evidence Syntheses Inventory ('best evidence syntheses' on clinical management) reviews that are living, up to date, high quality and where there is a GRADE evidence profile. LIVING Project - living systematic review of COVID-19 interventions; L*VE/Epistemonikos, VA COVID-19 Evidence Reviews; GIN COVID-19 Evidence Resources EvidenceAid Usher Network for COVID-19 Evidence Reviews
Current Standards	EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation Vocabulary Map for Evidence-related resources[ Project Google Drive ])
Emerging Standards
Initiatives
Tools/ Platforms	Resources and tools for researchers considering and conducting COVID-19 evidence syntheses (From COVID-END Synthesizing WG) GIN COVID-19 Evidence Resources SRDR+, Covidence, Distiller SR, RevMan, JBI Sumari Doctor Evidence Analytics Tool
Other Best Practices	COVID-NMA has initiated communication with all trialists to try to ensure consistent approaches e.g. selection of outcomes, reduction of risk of bias, and to invite them to contribute missing data.

Produce Guidance

	General Recommendations	Anticoagulation	Testing/Triage
Input Sources	See Output Repositories from Synthesize Evidence table	ASH Living Guideline on COVID anticoagulation and underlying justification and evidence tables (critically ill and acutely ill) NIH Guideline AU living Guideline NEJM vignette with expert opinion	BMJ/Remote Triage in Ambulatory Care
Search Strategies
Output Repositories	Living Map of COVID-19 recommendations (Canadian Institutes of Health Research) ECRI COVID-19 Guideline Resources GIN will publish (has published?) a registry of guidelines in development (COVID and beyond)
Current Standards
Emerging Standards
Initiatives
Tools/ Platforms	GIN COVID-19 Guidance Resources MAGICapp; COVID-END Rapid Response Model and Tips/Tools GRADE International Patient Decision Aid Standards 9/15/20 Annals IM article on COVID guidelines. AGREE II for assessing guideline quality and reporting; Africa Centre for Evidence Living Hub of COVID-19 Knowledge Hubs
Other Best Practices	COVID-END Recommending WG guidance on producing COVID-19 Guidelines [to be released soon] 2011 NAM (IOM) Standards for Guidelines Guideline development resources: GIN/McMaster Checklist, Australia Guidelines for Guidelines Handbook Methodologies for the Development of CHEST Guidelines and Expert Panel Reports

Make Guidance Computable

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources	See output repositories under Produce Guidance
Output Repositories	CDS Connect Repository
Current Standards	CPG on FHIR BPM+ Logica-led Care Management Implementation Guide [standards and guidance] to cultivate synergies between CPG on FHIR and BPM+ [in development - e.g., see info on Care Management Track at 2020-09 Connectathon]) CDS Hooks; SMART on FHIR COVID-19 Interoperability Alliance Value Sets Logica COVID-19 FHIR Profile Library IG
Emerging Standards	MCBK Standards WG Metadata work
Initiatives
Tools/ Platforms	CDS Connect Authoring Tool
Other Best Practices

Implement Guidance (e.g., as CDS, eCQMs)

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources	See output repositories for Make Guidance Computable
Current Standards
Emerging Standards
Initiatives	C19 Digital Guidelines WG developing and implementation guide for COVID-19 interventions
Tools/ Platforms
Other Best Practices	HITEQ Center Guide to Improving Care Processes and Outcomes HIMSS Improving Outcomes with CDS

Analyze Care Results

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources
Search Strategies
Output Repositories
Current Standards
Emerging Standards	MCBK Standards WG Metadata work
Initiatives
Tools/ Platforms	eCQI Resource Center UMich/MCBK Knowledge Grid efforts MCBK UK ‘knowledge hackathons’ to implement NICE guidelines AHRQ-funded toolkit for ePROs in patient care NQF project to create a measurement framework linking quality of care delivered by telehealth, healthcare system readiness, and health outcomes in a disaster
Other Best Practices

Leverage Results Analysis (e.g., for Quality Improvement, Reporting, and Evidence Generation)

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources
Search Strategies
Output Repositories
Current Standards	EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation) Vocabulary Map for Evidence-related resources [Project Google Drive] DEQM FHIR IG FHIR Electronic Case Reporting
Emerging Standards
Initiatives	MedMorph
Tools/ Platforms
Other Best Practices

Knowledge Ecosystem Recommendations

Overview

Recommendation Tables for Knowledge Ecosystem Steps

Identify Studies

Synthesize Evidence

Produce Guidance

Make Guidance Computable

Implement Guidance (e.g., as CDS, eCQMs)

Analyze Care Results

Leverage Results Analysis (e.g., for Quality Improvement, Reporting, and Evidence Generation)