Overview

This page is a resource to help stakeholders working along the COVID-19 evidence-to guidance- to action - to data - to evidence cycle improve their work processes and results. The ultimately goal is to a soon as possible, improve COVID-19 care delivery and outcomes.
The tables below are designed to aggregate Collaborative participant recommendations for addressing steps in this COVID-19 knowledge ecosystem. The recommended tools and approaches are being gathered and will evolve over time as stakeholder input is received and community consensus around best practices - and the pandemic itself - evolve.

Recommendation Tables for Knowledge Ecosystem Steps

Table List

Identify Studies
Synthesize Evidence
Produce Guidance
Make Guidance Computable
Implement Guidance
Analyze Care Results
Leverage Results Analysis (e.g., for Quality Improvement, Reporting, Evidence Generation)

	General Recommendations	Testing/Triage
Input Sources	L*VE/Epistemonikos Cochrane COVID-19 study register NIPH COVID-19 Living Evidence Map MedRxiv ClinicalTrials.gov/COVID-19 New pubmed interface DoctorEvidence CORD-19 Dataset Search	NEWS2 predicts severity/mortality at admission Annals IM, hospitalized patient trajectories Sensitivity, Specificity Predictive Values of Tests for COVID-19 in ED PREDI-CO Risk assessment tool
Search Strategies
Output Repositories
Current Standards
Emerging Standards
Initiatives	Librarian Reserve Corps COVID-Evidence Project - building a database to gather all the evidence around a drug (University of Basil - currently focused on hydroxychloroquine, but model could be adaptable to other targets) Identification of sources to identify primary studies - validation study of specialized COVID-19 databases (systematic reviewers are going to different sources - this effort is to identify best practices) Advocate for librarian representation in searches and reviews - leverage skillsets/best practices in this work [SLMC]: close gaps between needs that clinicians are seeing on the front line and topics covered in reviews guidelines COKA Evidence/ Tools WG [Project Google Drive](work in process)
Tools/ Platforms
Other Best Practices

	General Recommendations	Anticoagulation	Testing/Triage
Input Sources	See Sources/Repositories from Identify Studies table ClinicalTrials.gov/COVID-19; New pubmed interface; DoctorEvidence CORD-19 Dataset Search	Underlying justification and evidence tables (critically ill and acutely ill) from ASH Anticoagulation Living Guidelines L*VE/Epistemonikos search on antithrombotics; can send email when new study/review/guideline is published. Rapid Cochrane review on anticoagulation in COVID-19 patients	BMJ EBM rapid review on COVID tests
Output Repositories	SRDR COVID NMA Project COVID-END Best Evidence Syntheses Inventory reviews that are living, up to date, high quality and where there is a GRADE evidence profile.
Current Standards	EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation Vocabulary Map for Evidence-related resources[ Project Google Drive ])
Emerging Standards
Initiatives
Tools/ Platforms	Resources and tools for researchers considering and conducting COVID-19 evidence syntheses (From COVID-END Synthesizing WG)
Other Best Practices	COVID-NMA has initiated communication with all trialists to try to ensure consistent approaches e.g. selection of outcomes, reduction of risk of bias, and to invite them to contribute missing data.

	General Recommendations	Anticoagulation
Input Sources	See Output Repositories from Synthesize Evidence table	ASH Living Guideline on COVID anticoagulation and underlying justification and evidence tables (critically ill and acutely ill) NIH Guideline AU living Guideline NEJM vignette with expert opinion
Search Strategies
Output Repositories
Current Standards
Emerging Standards
Initiatives
Tools/ Platforms
Other Best Practices	COVID-END Recommending WG guidance on producing COVID-19 Guidelines [to be released soon] 2011 NAM (IOM) Standards for Guidelines

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources
Search Strategies
Output Repositories
Current Standards
Emerging Standards
Initiatives
Tools/ Platforms
Other Best Practices

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources
Search Strategies
Output Repositories
Current Standards
Emerging Standards
Initiatives
Tools/ Platforms
Other Best Practices

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources
Search Strategies
Output Repositories
Current Standards
Emerging Standards
Initiatives
Tools/ Platforms
Other Best Practices

	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Input Sources
Search Strategies
Output Repositories
Current Standards	EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation) Vocabulary Map for Evidence-related resources [Project Google Drive] DEQM FHIR IG FHIR Electronic Case Reporting
Emerging Standards
Initiatives
Tools/ Platforms
Other Best Practices