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The Agency for Healthcare Research and Quality (AHRQ) provides many valuable evidence-based resources and tools for patients, providers, policymakers, researchers, systematic reviewers, guideline developers, and many other healthcare stakeholders. These offerings are spread across over ~20 different websites with different structures, content types, and purposes. This can make it difficult for potential users to appreciate that AHRQ has resources useful to address their needs, find these resources, and integrate them into their workflows and information systems.

These challenges are dramatically amplified from the user perspective given the myriad other public and private resources to meet their information and support needs. As a result, critical healthcare decisions and actions are often not informed by the important evidence, guidance, and tools that are available. Such problematic information and resource flow is a major contributor (1) (2) (3) to suboptimal performance in healthcare quality, cost, safety, patient satisfaction, and provider well-being (see Urgent Challenge: Put Evidence into Practice More Effectively).

AHRQ established the AHRQ evidence-based Care Transformation Support (ACTS) initiative in late 2018 to propose a Roadmap to make its evidence-based tools and resources—along with those from many other public and private sources—easy to find and apply by healthcare stakeholders who need them. To ensure that any eventual AHRQ efforts to implement the Roadmap leverage and support related efforts by others, the ACTS project team engaged a broad Stakeholder Community. Several workgroups were formed during 2019 to provide input and establish foundations for the Roadmap. During 2020, three AHRQ-funded pilot efforts were initiated with the Stakeholder Community to explore key Roadmap components.

The Stakeholder Community grew steadily throughout 2019 and 2020, reaching nearly 300 members by the end of 2020. The ACTS Roadmap is a 10-year plan to produce a robust digital healthcare knowledge ecosystem anchored by an AHRQ Digital Knowledge Platform (DKP). This Roadmap requires a substantial Federal investment to seed critical activities, which will then inspire and be amplified by complimentary private-sector investment. This knowledge ecosystem will make evidence, guidance, tools, and resources from AHRQ—and other public and private sources—more FAIR (i.e., findable, accessible, interoperable, reusable); computable; and useful.

The goal is to have the knowledge ecosystem broadly support learning health systems (LHSs) and realization of the Quintuple Aim. In addition to these benefits, it is estimated that billions of public and private-sector dollars could be saved annually (4) (5) (6) by reducing waste in healthcare delivery and redundancies and inefficiencies in resource development (see Value Proposition & ROI).

Table of Contents

To help ensure


Roadmap execution delivers


on the goal, initial


efforts focus on


four high priority clinical targets




  1. COVID19/pandemic response
  2. preventive care;
  3. hypertension control; and
  4. pain management

Additional targets will be added as execution progresses, and efforts to improve the knowledge ecosystem function for all these targets will be designed to scale to many other targets via efforts that unfold synergistically and in parallel with those specifically addressed by this Roadmap.


The Roadmap is divided into four phases: Concept Demonstrations (2021–2024), Pilots (2024–2027), Scaling (2027–2030), and LHS (2031).

Each phase includes tasks organized around five critical activities: Create/Use Governance; Collaboration; Enhance/Leverage Infrastructure; Enhance/Develop Living, Computable Guidance; Enhance Guidance Implementation and Assessment; and Evaluate/Plan Roadmap Execution.

Together, the tasks are designed to improve the entire knowledge ecosystem cycle (i.e., from evidence to guidance to action to data and back to evidence).

Initial AHRQ-funded pilots to address Roadmap activities


are currently underway


. The ACTS project team has received letters from


stakeholder organizations expressing support for the ACTS Future Vision and interest in cultivating synergies between their efforts and Roadmap-recommended approaches to broadly realizing that future vision.



Urgent Challenge: Put Evidence into Practice More Effectively

Healthcare outcomes in the United States are far from optimal. Patients' care experiences are often frustrating and fragmented—lacking clear care plans, plagued by slow or missing communication and unclear or unshared priorities, and fraught with challenges to access critically needed information and tools. Patients often are not fully engaged in reconciling their care goals with those of their clinicians to achieve important results. Furthermore, the United States has the poorest healthcare outcomes among 11 high-income countries, even though it spends the most (7). According to the Centers for Medicare and Medicaid Services (CMS), the United States spent 17.7% of its 2019 Gross Domestic Product (GDP) on healthcare—and costs are rising (8). A 2019 peer review of literature from 2012 to 2019 estimated approximately 30% of healthcare spending could be considered waste, resulting in a staggering total annual waste estimate of $760 billion to $935 billion and a potential $191 billion to $286 billion in savings from interventions that address waste, including in the following domains pertinent to this Roadmap (4):

  • Failure of care delivery: $44.4 billion to $97.3 billion
  • Failure of care coordination: $29.6 billion to $38.2 billion
  • Overtreatment or low-value care: $12.8 billion to $28.6 billion


Figure 3. Current Barriers to an Effective LHS Cycle
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In this broken supply chain, data, knowledge, information—and access to them—are siloed in disparate systems that are not interoperable. This problem is pervasive throughout the entire healthcare system, leading to inefficiencies, lost time and productivity, and undesirable outcomes. For example, healthcare organizations often experience difficulties to:

  • Find, evaluate, access, and integrate into systems the data, evidence, guidance, and tools needed to support critical business decisions, products, and actions
  • Apply pertinent data, guidance, and tools within time-pressured workflows
  • Leverage complex and evolving standards to address business needs
  • Manage increasing costs and challenges associated with public health, care quality, process efficiency, stakeholder satisfaction, and other key outcomes
  • Interact effectively with the complex web of information "suppliers" and "customers" to deliver value

More specifically, there are significant missed opportunities at critical junctures along the LHS cycle. Data reflecting care results are frequently not used well to improve the evidence base because it is typically difficult and expensive to gather, incomplete, and/or inaccurate. This limited data scope yields evidence that does not address many important questions. Further, the evidence is often inconsistent and not in a standardized format, making it difficult to process into readily updatable knowledge, tools, and resources that support care delivery and transformation. The many support offerings that already exist are difficult to locate and apply. They often do not fit smoothly into workflow and can require major investments to acquire and deploy in health IT systems. The poor interoperability and flow from data to evidence to guidance to tools that support critical decisions and actions and back to data about care results is depicted in Figure 4. Current Healthcare Information Flow). This current state is a major driver for the preventable problems with care and patient outcomes, unnecessarily high expenditures, suboptimal patient experience, and overburdened clinicians noted above. <ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="01e10289-94ec-4617-85cd-cf5955f280a6"><ac:parameter ac:name="">_Ref60735279</ac:parameter></ac:structured-macro><span style="color: #262626">Figure 4.<ac:structured-macro ac:name="anchor" ac:schema-version="1" ac:macro-id="e3da25cd-dbe7-4523-8eac-f4f993a91e67"><ac:parameter ac:name="">_Ref56414265</ac:parameter></ac:structured-macro></span> <span style="color: #262626">Current Healthcare Information Flow</span> !worddav3e459d814a2972a4d0ded15a3f8c09aa.png|height=409,width=384! These challenges led healthcare leaders to establish the <span style="color: #262626"><strong>Quintuple Aim</strong></span> (22) (23)—a goal where the healthcare system simultaneously enhances patient experience, improves population health, reduces costs, and improves clinician experience. Health information technology (IT) is widely considered a key enabler to improve information flow and achieve the Quintuple Aim. While there have been major investments in health IT (including artificial intelligence \[AI\] and cloud computing infrastructure), substantial standards efforts, and regulations around _data_ interoperability, there remains a chasm between the kind of transformation achieved in other industries and that seen in healthcare (2). There is growing consensus that health IT-enabled care transformation delivered through an LHS, both at the enterprise and national levels, supported by evidence and knowledge interoperability that complements data interoperability, is the solution to these deficiencies (24). There have been major efforts over decades to address these problems, and this ACTS Roadmap builds on these efforts, a sampling of which includes: 

  • Crossing the Quality Chasm, Institute of Medicine (IOM), 1996–2006 (1)
  • Roadmap for National Action on Clinical Decision Support (CDS), The Office of the National Coordinator for Health Information Technology (ONC) / American Medical Informatics Association (AMIA), 2006 (25)
  • Knowing What Works in Healthcare: A Roadmap for the Nation, 2008 (26)
  • Driving Quality and Performance Measurement—A Foundation for CDS, 2010 (27)
  • Optimizing Strategies for CDS, 2017 (28)

Full realization of LHSs and the Quintuple Aim in follow-up to these important initaitives have been impeded by forces such as:

  • The lack of a specific, shared vision for how the cycle is supposed to function to help drive and coordinate enhancement efforts
  • Inadequate funding and incentives to make these improvements
  • The lack of widely adopted standards to improve resource development, interoperability, and implementation

This ACTS Roadmap deliverable builds on prior work and leverages more robust and widely adopted critical standards (e.g., Fast Healthcare Interoperability Resources \[FHIR\], more ubiquitous and sophisticated health IT (developed with greater attention to user-centered design), increased interest in value-based care and LHSs, and greater attention to stakeholder-driven approaches to accelerate transformation. These developments should substantially accelerate progress toward the Quintuple Aim beyond what these prior initiatives achieved. This Roadmap focuses on the problems and solutions that AHRQ and other knowledge ecosystem stakeholders can directly address by replacing the broken cycle, shown in Figure 3. Current Barriers to an Effective LHS Cycle and Figure 4. Current Healthcare Information Flow with an effective LHS cycle, shown in Figure 5. The LHS Cycle. In this effective LHS cycle, public health, care delivery, and quality improvement (QI) actions produce data about results, which is processed into evidence about effective actions, which is in turn processed into knowledge, tools, and resources that inform subsequent action—in a continuous cycle—to achieve the Quintuple Aim. Producing an effective LHS cycle requires that information flows seamlessly around that cycle. The environment in which people use processes and technology to address this flow in ways that deliver desired outcomes we call the "knowledge ecosystem."

Functionally, the knowledge ecosystem enables the LHS cycle, which we also refer to as the "knowledge ecosystem cycle."

Figure 5. The LHS Cycle

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The CDS 5 Rights Framework (29), is a widely cited approach for putting evidence, guidance, and tools into practice better—that is, for optimizing the _guidance to action_ portion of the knowledge ecosystem cycle. The framework, recommended by CMS as a health IT / QI best practice (30), asserts that optimizing a particular healthcare process or outcome requires getting the information (e.g., evidence-based and actionable) to the right people (e.g., care teams and patients) in the right formats (e.g., registry reports, documentation tools, data display, care plans) through the right channels (e.g., electronic health record \[EHR\], personal health record \[PHR\], smartphones, smart home devices) at the right times (e.g., during a key decision or action). This framework can be extended to cover the _entire_ LHS cycle by broadening each of the five dimensions to include _all_ the pertinent who, what, when, where, how options.

Figure 6. The Decision/Action Support (DAS) 5-Rights-Supported LHS Cycle illustrates how the LHS virtuous cycle requires addressing well each of those five dimensions throughout all activities in the cycle.

Figure 6. The Decision/Action Support (DAS) 5-Rights-Supported LHS Cycle

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Figure 7. LHS Functions That the Knowledge Ecosystem Supports illustrates additional details about processes performed around the knowledge ecosystem cycle. Each of these processes is an opportunity to put the DAS 5 Rights Framework into action to make them efficient and well-coordinated to achieve a virtuous LHS cycle.

Figure 7. LHS Functions That the Knowledge Ecosystem Supports

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Why AHRQ Launched This Effort

AHRQ produces many valuable, evidence-informed resources to support care delivery and transformation and LHSs. However, many who could significantly benefit from these resources aren't aware they exist, have difficulty finding or accessing them, or are challenged to incorporate them into information systems and workflow. To promote broader value from these carefully curated resources, AHRQ launched the ACTS Initiative (31) in late 2018 to develop a roadmap for how to improve access to and use of resources that AHRQ and others provide. That is, to chart a path for how the Agency could better realize its mission (32) (33) by creating an AHRQ DKP that makes its resources more FAIR (34), computable, and useful, and, most importantly, does this in a manner synergistic with other public and private efforts to likewise mobilize computable biomedical information into an integrated knowledge ecosystem that supports LHSs, the DAS 5 Rights, and the Quintuple Aim in ways that help achieve respective organizational missions.

See Figure 8. Sampling of Non-AHRQ Initiatives Addressing the Knowledge Ecosystem With Which Roadmap Execution Coordinates and Appendix A, Interplay With a Sampling of Other Strategic Plans, Priorities & Initiatives for examples of these other important and inter-related activities.

Figure 8. Sampling of Non-AHRQ Initiatives Addressing the Knowledge Ecosystem With Which Roadmap Execution Coordinates

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[N] indicates not a Federal initiative.  See Appendix H, Acronyms & Abbreviations for definitions. 

Needed: Better DKPs



Finally, this site is a great way to learn about the Roadmap, the concept demo, next steps and how YOU and your organization can get involved to achieve the future vision. The links below will get you started.

Why ACTS - the Urgent Challenge

Why AHRQ Launched this Effort

Learn more about why better DKPs are needed


Consensus Future Vision for Evidence-Informed, Health IT Enabled Care Delivery & Transformation

Creating LHSs at organization, national, and international scales is increasingly viewed as a core strategy to optimize healthcare delivery and achieve the Quintuple Aim (57) (58). Computable knowledge is a key enabler for these LHSs (3). By illustrating how health IT that supports the interoperable flow of computable knowledge around the knowledge ecosystem and LHS cycle, Figures 5–11 and 13 reflect key future vision elements for broadly realizing LHSs. In this future vision, resources needed to support key decisions and actions throughout the knowledge ecosystem cycle are FAIR (59) (see Figure 14. Characteristics of FAIR Resources), computable, useful, and widely used to great benefit.
Enhanced information flow in the knowledge ecosystem and LHS cycle should produce continuously improving public health, and care quality and outcomes. Evidence is effectively translated into resources that are widely and successfully used to guide actions, which generate useful data that inform more robust evidence in a virtuous learning cycle (see What a Digital Knowledge Ecosystem Will Enhance). Stakeholders in each area of the cycle must have clear economic incentives naturally guiding local policies and behaviors toward this model. We refer to this overall cycle as a national LHS cycle when it encompasses efforts across an entire country. An ultimate Roadmap goal is data, evidence, knowledge, guidance, and tools that are computable and interoperable across national, geographic, policy, and other boundaries in ways that enable the virtuous cycle to encompass everyone, everywhere. The COVID19 pandemic reinforces the need for such a global learning and improvement cycle.
Individual CDOs can likewise become LHSs by supporting helpful evidence-based information and tools use in practice by care teams, quality teams and patients (e.g., through evidence-based, integrated care plans); systematically examining results from their care delivery and QI efforts; and using these results to enhance care and QI efforts continuously. We refer to this CDO-specific work as the organizational LHS cycle. CDOs and entities that support them typically refer to these activities as QI, continuous QI (CQI), or care transformation.
The ACTS Future Vision Workgroup described in detail desirable workflows and information flows that could occur in LHSs supported by a high-functioning knowledge ecosystem (Appendix B, Future Vision). Four knowledge ecosystem perspectives were selected for this visioning work:

  • Those who are involved in receiving and giving healthcare (B.3, Care Delivery Perspective of the ACTS Future Vision)
  • Those who produce the evidence, knowledge, and guidance resources that support public health, care delivery and other activities around the LHS cycle (B.4, Resource Developers' Perspective of the ACTS Future Vision)
  • Those involved in QI activities in CDOs (B.5.1, Organizational LHS Future Vision Perspective)
  • And those involved in driving LHS implementation at the national level (B.5.2, National LHS Future Vision Perspective)

Figure 15. Future Vision for a Virtuous LHS Cycle includes a one-sentence future vision overview for each of these perspectives, encapsulating many pages of detailed descriptions presented in the future vision appendix.
Other future vision perspectives not addressed by the Future Vision Workgroup are also essential for driving a knowledge ecosystem that delivers LHSs. For example, defining desirable specifics for the data-to-evidence portion of the LHS cycle as depicted in Figure 15. Future Vision for a Virtuous LHS Cycle. The Roadmap is designed to support stakeholders in defining and addressing a consensus future vision for these key ecosystem components in ways that leverage and advance related initiatives to collect and analyze data to generate new evidence (60) (61) (62) (63) and for related LHS cycle activities. The LHS cycle—and the outcomes it should deliver such as the Quintuple Aim—will only be as successful as permitted by the least effective cycle component, so careful attention must be paid to all components.

Figure 14. Characteristics of FAIR Resources Adapted from (347) and (59)