Recommendation Tables for Knowledge Ecosystem Steps

Identify

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Studies [Consider Merging this into Synthesize Evidence Table]

	General Recommendations	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Key Definitions and Frameworks
What to know/do Overview
Input Sources	L*VE/Epistemonikos Cochrane COVID-19 study register NIPH COVID-19 Living Evidence Map MedRxiv ClinicalTrials.gov/COVID-19 New pubmed interface DoctorEvidence CORD-19 Dataset Search EBSCO COVID-19 Information Portal University of Michigan COVID-19 Best Evidence Front Door	NEWS2 predicts severity/mortality at admission Annals IM, hospitalized patient trajectories Sensitivity, Specificity Predictive Values of Tests for COVID-19 in ED PREDI-CO Risk assessment tool	For steroids systematic meta-review, 8 sources have been identified these are (MEDLINE, CORD-19, L-OVE/Episteminokos, NIH iSearch COVID-19, EuropePMC, WHO COVID-19 Database, EMBASE + Prospero)
Search Strategies
Output Repositories
Standards
Initiatives	Librarian Reserve Corps COVID-Evidence Project - building a database to gather all the evidence around a drug (University of Basil - currently focused on hydroxychloroquine, but model could be adaptable to other targets) Identification of sources to identify primary studies - validation study of specialized COVID-19 databases (systematic reviewers are going to different sources - this effort is to identify best practices) Advocate for librarian representation in searches and reviews - leverage skillsets/best practices in this work [SLMC]: close gaps between needs that clinicians are seeing on the front line and topics covered in reviews guidelines COKA Evidence/ Tools WG [Project Google Drive](work in process)
Tools/ Platforms
Other Best Practices	Framework slides: Applying Standards to the Evidence Domain (from the COKA Evidence Ecosystem Liaison WG)

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	General Recommendations	Anticoagulation	Testing/Triage	Other (Long COVID, Vaccine, Steroids)
Key Definitions and Frameworks	includes evaluation of quality of evidence also needs to address processing of real world evidence [weave in ICER - search ISER opioids]
What to know/do Overview	For people creating evidence syntheses See if work on planned topic has been done already - search L*VE/Epistemonikos (2K reviews - cover many questions - only a fraction registered in PROSPERO; most reviews are out of date - only 3% have all the trials they should), PROSPERO for what's in the pipeline. Make sure that any existing reviews look at outcomes that are pertinent to your needs [leverage COMET - outcome measures], etc. that of interest for the need at hand. Very hard for user to identify a review that's up to date. COVID-END repository of Best Evidence Syntheses can be helpful here. Need to have access to raw data that fed into the review so it's more re-usable. important to understand end-user needs so that the review can be aimed at addressing them AHRQ has methods guides, Cochrane has them. Are there tools for this on COVID - e.g., Resources and tools for researchers considering and conducting COVID-19 evidence syntheses (From COVID-END Synthesizing WG) For organizations consuming evidence syntheses For selecting/using synthesized evidence: Is there a GRADE evidence profile? Do they make quality assessments? How comprehensive are they? Search date
Input Sources	See Sources/Repositories from Identify Studies table ClinicalTrials.gov/COVID-19; New pubmed interface; DoctorEvidence CORD-19 Dataset Search PROSPERO	Underlying justification and evidence tables (critically ill and acutely ill) from ASH Anticoagulation Living Guidelines L*VE/Epistemonikos search on antithrombotics; can send email when new study/review/guideline is published. Rapid Cochrane review on anticoagulation in COVID-19 patients	BMJ EBM rapid review on COVID tests
Output Repositories	SRDR+ COVID NMA Project COVID-END Best Evidence Syntheses Inventory ('best evidence syntheses' on clinical management) reviews that are living, up to date, high quality and where there is a GRADE evidence profile. LIVING Project - living systematic review of COVID-19 interventions; L*VE/Epistemonikos, VA COVID-19 Evidence Reviews; GIN COVID-19 Evidence Resources EvidenceAid Usher Network for COVID-19 Evidence Reviews
Standards	EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation Vocabulary Map for Evidence-related resources[ Project Google Drive ])
Initiatives				COKA Steroids for COVID-19 Systematic Meta-Review Protocol; slides about this effort
Tools/ Platforms	Resources and tools for researchers considering and conducting COVID-19 evidence syntheses (From COVID-END Synthesizing WG) GIN COVID-19 Evidence Resources SRDR+, Covidence, Distiller SR, RevMan, JBI Sumari Doctor Evidence Analytics Tool
Other Best Practices	COVID-NMA has initiated communication with all trialists to try to ensure consistent approaches e.g. selection of outcomes, reduction of risk of bias, and to invite them to contribute missing data. Framework slides: Applying Standards to the Evidence Domain (from the COKA Evidence Ecosystem Liaison WG)

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	General Recommendations	Anticoagulation	Testing/Triage
Key Definitions and Frameworks
What to know/do Overview
Input Sources	See Output Repositories from Synthesize Evidence table	ASH Living Guideline on COVID anticoagulation and underlying justification and evidence tables (critically ill and acutely ill) NIH Guideline AU living Guideline NEJM vignette with expert opinion	BMJ/Remote Triage in Ambulatory Care
Output Repositories	Living Map of COVID-19 recommendations (Canadian Institutes of Health Research) ECRI COVID-19 Guideline Resources GIN will publish (has published?) a registry of guidelines in development (COVID and beyond)
Standards
Initiatives
Tools/ Platforms	GIN COVID-19 Guidance Resources MAGICapp; COVID-END Rapid Response Model and Tips/Tools GRADE International Patient Decision Aid Standards 9/15/20 Annals IM article on COVID guidelines. AGREE II for assessing guideline quality and reporting; Africa Centre for Evidence Living Hub of COVID-19 Knowledge Hubs
Other Best Practices	COVID-END Recommending WG guidance on producing COVID-19 Guidelines [to be released soon] 2011 NAM (IOM) Standards for Guidelines Guideline development resources: GIN/McMaster Checklist, Australia Guidelines for Guidelines Handbook Methodologies for the Development of CHEST Guidelines and Expert Panel Reports

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Recommendation Tables for Knowledge Ecosystem Steps

Identify

Studies [Consider Merging this into Synthesize Evidence Table]

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Összehasonlított verziók

Régi verzió 19

Új verzió 20

Kulcs

Recommendation Tables for Knowledge Ecosystem Steps

Identify

Studies [Consider Merging this into Synthesize Evidence Table]