• L*VE/Epistemonikos
• Cochrane COVID-19 study register
• NIPH COVID-19 Living Evidence Map
• MedRxiv
• ClinicalTrials.gov/COVID-19
• New pubmed interface
• DoctorEvidence CORD-19 Dataset Search
• EBSCO COVID-19 Information Portal
• University of Michigan COVID-19 Best Evidence Front Door 

• NEWS2 predicts severity/mortality at admission
• Annals IM, hospitalized patient trajectories
• Sensitivity, Specificity Predictive Values of Tests for COVID-19 in ED
• PREDI-CO Risk assessment tool

• For steroids systematic meta-review, 8 sources have been identified these are (MEDLINE, CORD-19, L-OVE/Episteminokos, NIH iSearch COVID-19, EuropePMC, WHO COVID-19 Database, EMBASE + Prospero) 

• Librarian Reserve Corps
  • COVID-Evidence Project - building a database to gather all the evidence around a drug (University of Basil - currently focused on hydroxychloroquine, but model could be adaptable to other targets)
  • Identification of sources to identify primary studies - validation study of specialized COVID-19 databases (systematic reviewers are going to different sources - this effort is to identify best practices)
  • Advocate for librarian representation in searches and reviews - leverage skillsets/best practices in this work
    [SLMC]: close gaps between needs that clinicians are seeing on the front line and topics covered in reviews guidelines
• COKA Evidence/ Tools WG [Project Google Drive](work in process)

• Framework slides: Applying Standards to the Evidence Domain (from the COKA Evidence Ecosystem Liaison WG)

• See Sources/Repositories from Identify Studies table
• ClinicalTrials.gov/COVID-19; New pubmed interface; DoctorEvidence CORD-19 Dataset Search
• PROSPERO

• Underlying justification and evidence tables (critically ill and acutely ill) from ASH Anticoagulation Living Guidelines
• L*VE/Epistemonikos search on antithrombotics; can send email when new study/review/guideline is published.
• Rapid Cochrane review on anticoagulation in COVID-19 patients

• BMJ EBM rapid review on COVID tests

• SRDR+
• COVID NMA Project
• COVID-END Best Evidence Syntheses Inventory ('best evidence syntheses' on clinical management)
  • reviews that are living, up to date, high quality and where there is a GRADE evidence profile. 
• LIVING Project - living systematic review of COVID-19 interventions;
• L*VE/Epistemonikos, 
• VA COVID-19 Evidence Reviews;
• GIN COVID-19 Evidence Resources
• EvidenceAid
• Usher Network for COVID-19 Evidence Reviews

• EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation
• Vocabulary Map for Evidence-related resources[ Project Google Drive])

• COKA Steroids for COVID-19 Systematic Meta-Review Protocol; slides about this effort

• Resources and tools for researchers considering and conducting
  COVID-19 evidence syntheses (From COVID-END Synthesizing WG)
• GIN COVID-19 Evidence Resources
• SRDR+, Covidence, Distiller SR, RevMan, JBI Sumari
• Doctor Evidence Analytics Tool

• COVID-NMA has initiated communication with all trialists to try to ensure consistent approaches e.g. selection of outcomes, reduction of risk of bias, and to invite them to contribute missing data. 
• Framework slides: Applying Standards to the Evidence Domain (from the COKA Evidence Ecosystem Liaison WG)

• See Output Repositories from Synthesize Evidence table

• ASH Living Guideline on COVID anticoagulation and underlying justification and evidence tables (critically ill and acutely ill)
• NIH Guideline
• AU living Guideline
• NEJM vignette with expert opinion

• BMJ/Remote Triage in Ambulatory Care

• Living Map of COVID-19 recommendations (Canadian Institutes of Health Research)
• ECRI COVID-19 Guideline Resources
• GIN will publish (has published?) a registry of guidelines in development (COVID and beyond)

• GIN COVID-19 Guidance Resources
• MAGICapp; 
• COVID-END Rapid Response Model and Tips/Tools
• GRADE
• International Patient Decision Aid Standards
• 9/15/20 Annals IM article on COVID guidelines. 
• AGREE II for assessing guideline quality and reporting;
• Africa Centre for Evidence Living Hub of COVID-19 Knowledge Hubs

• COVID-END Recommending WG guidance on producing COVID-19 Guidelines [to be released soon]
• 2011 NAM (IOM) Standards for Guidelines
• Guideline development resources: GIN/McMaster Checklist, Australia Guidelines for Guidelines Handbook
• Methodologies for the Development of CHEST Guidelines and Expert Panel Reports 

• See output repositories under Produce Guidance

• CDS Connect Repository

• CPG on FHIR
• BPM+
• Logica-led Care Management Implementation Guide [standards and guidance] to cultivate synergies between CPG on FHIR and BPM+ [in development - e.g., see info on Care Management Track at 2020-09 Connectathon]) 
• CDS Hooks;
• SMART on FHIR
• COVID-19 Interoperability Alliance Value Sets
• Logica COVID-19 FHIR Profile Library IG

• [under development] MCBK Standards WG Metadata work

• CDS Connect Authoring Tool

From C19HCC Digital Guideline WG:

• Using CPG-on-FHIR standard for representing/ expressing the full intent of the Guidance in computer-interpretable artifacts (part of HL7 CPG-IG)
• Using the Agile Approach to CPG Development (inclusive of Integrated Process) to concurrently Produce Guidance and Make Guidance Computable (part of HL7 CPG-IG)
• Use Agile Knowledge Engineering methods, principles, and tools
  • Cross-functional Integrated team (Agile CPG Team)
  • Leverage composite nature of CPGs (e.g. can develop logic for inferences on patient information- CPG_CaseFeatures) to build incrementally and iteratively with rapid feedback
  • Pull knowledge engineers into Content design/reviews; pull domain SMEs into knowledge representation design/reviews
• Leverage CPG-on-FHIR as a faithful expression of Guidance and its ability to create computationally derived CDS and Cognitive Support, patient-specific, practice-level digital Quality Measures/Metrics, eCaseReports, etc. to create computable artifacts used downstream in the Learning Health System and to provide closed-loop feedback/feedforward.
• Leverage established tools and capabilities (e.g. BPM+ process and tooling, Clinical Ontology) to author computable Guidance and Open Source tooling to translated into HL7 CPG-on-FHIR to leverage derivative and native compute
• tips:
  • Use established standards and work with standards community (to understand and evolve as needed)
  • Engage consumers/ users early and often
  • Engage downstream vendors (e.g Terminology vendor USED in the EHRs) early
  • Just because everyone everyone is using the same terminology systems doesn't mean they're agreeing how to use the actual terms- this needs to be considered and addressed to make ecosystem/supply chain work properly (feedforward from Evidence, but also feedback of data semantics back into evidence)
  • Learn from related communities of practice (e.g. Agile Software Engineering)

• See output repositories for Make Guidance Computable

• C19 Digital Guidelines WG developing and implementation guide for COVID-19 interventions

• HITEQ Center Guide to Improving Care Processes and Outcomes
• HIMSS Improving Outcomes with CDS

• [under development] MCBK Standards

• WG Metadata work

• eCQI Resource Center
• UMich/MCBK Knowledge Grid efforts
• MCBK UK ‘knowledge hackathons’ to implement NICE guidelines
• AHRQ-funded toolkit for ePROs in patient care
• NQF project to create a measurement framework linking quality of care delivered by telehealth, healthcare system readiness, and health outcomes in a disaster

• EBM on FHIR/COKA (standards include: Evidence, EvidenceReport, EvidenceVariable, Group, Citation)
• Vocabulary Map for Evidence-related resources [Project Google Drive]
• DEQM FHIR IG
• FHIR Electronic Case Reporting

• MedMorph